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Test Tubes
  • Zhou, X., Cao, H., Fang, SY. et al. CTLA-4 tail fusion enhances CAR-T antitumor immunity. Nat Immunol 24, 1499–1510 (2023).

  • Ye, L., Lam, S.Z., Yang, L. et al. AAV-mediated delivery of a Sleeping Beauty transposon and an mRNA-encoded transposase for the engineering of therapeutic immune cells. Nat. Biomed. Eng (2023).

  • Dai, X., Park, J.J., Du, Y. et al. Massively parallel knock-in engineering of human T cells. Nature Biotechnology 2023.

  • Ye, L., Park, J. J., Peng, L., Yang, Q., Chow, R. D., Dong, M. B., … & Chen, S. A genome-scale gain-of-function CRISPR screen in CD8 T cells identifies proline metabolism as a means to enhance CAR-T therapy. Cell Metabolism 2022. doi: 10.1016/j.cmet.2022.02.009 ​

  • Dai X*, Park JJ*, Du Y, Kim HR, Wang G, Errami Y, Chen S. One-step generation of modular CAR-T with AAV-Cpf1.  Nature Methods 2019. doi: 10.1038/s41592-019-0329

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